Large pharmaceutical companies collectively reduced their workforces by over 22,000 in 2025. This contraction occurred as the industry faces a $300 billion patent cliff. Many firms implemented cost cuts and layoffs to maintain profits. Pfizer, Novo Nordisk, and Sanofi were among those with significant reductions. Conversely, Eli Lilly and Amgen notably expanded their employee numbers.
https://www.fiercepharma.com/pharma/large-pharma-companies-reduced-headcount-over-22000-2025-300b-patent-cliff-looms