Layoffs and shareholder value destruction is what you get an industry's entire business model is no longer working and is falling apart. Layoffs, plus M&A / consolidation, and layoffs. Repeat the process until nothing valuable remains.
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The industry is maturing, all of what you said is not Sanofi specific, the whole industry is maturing and things will continue to develop in this directions: consolidation, M&A, layoffs, R&D cuts, slow pay growth, etc.